Development of a MALDI-TOF-MS Method for the Analysis of Cyanobacterial Neurotoxin β-N- Methylamino-L-alanine (BMAA) in Search of BMAA Incorporation in Biological Samples
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Cyanobacterial Neurotoxin β-N-Methylamino-L-alanine (BMAA) in Shark Fins
Sharks are among the most threatened groups of marine species. Populations are declining globally to support the growing demand for shark fin soup. Sharks are known to bioaccumulate toxins that may pose health risks to consumers of shark products. The feeding habits of sharks are varied, including fish, mammals, crustaceans and plankton. The cyanobacterial neurotoxin β-N-methylamino-L-alanine (...
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The cyanobacterial neurotoxin β-N-methylamino-L-alanine (BMAA) has been considered a serious health threat because of its putative role in multiple neurodegenerative diseases. First reports on BMAA concentrations in cyanobacteria were alarming: nearly all cyanobacteria were assumed to contain high BMAA concentrations, implying ubiquitous exposure. Recent studies however question this presence o...
متن کاملChemical Labeling Strategy and LC-MS/MS Analysis of Amine-containing Neurotoxin in Shark’s Fins
Introduction β-Methylamino-L-alanine (BMAA), is a neurotoxin and a nonproteinogenic amino acid. BMAA has been identified and quantified in cycad seeds and cyanobacteria by Rosen et al. using liquid chromatography tandem mass spectrometry without pre-derivatisation. Kushnir et al. has also developed a quantitative analysis of BMAA with iTRAQ reagent as derivative in biological samples and plant ...
متن کاملHuman Scalp Hair as an Indicator of Exposure to the Environmental Toxin β-N-Methylamino-l-alanine
Dietary or aerosol exposure to the environmental neurotoxin β-N-methylamino-l-alanine (BMAA) is a putative risk factor for the development of sporadic neurodegenerative disease. There are many potential sources of BMAA in the environment, but BMAA presence and quantities are highly variable. It has been suggested that BMAA in human hair may serve as an indicator of exposure. We sought to evalua...
متن کاملCyanobacterial Blooms and the Occurrence of the neurotoxin beta-N-methylamino-L-alanine (BMAA) in South Florida Aquatic Food Webs.
Recent studies demonstrate that most cyanobacteria produce the neurotoxin beta-N-methylamino-L-alanine (BMAA) and that it can biomagnify in at least one terrestrial food chain. BMAA has been implicated as a significant environmental risk in the development of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and Amyotrophic Lateral Sclerosis (ALS). We examined several...
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تاریخ انتشار 2017